scientific posters

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COMPARING THE MECHANICAL PROPERTIES OF QUALI-V^®-I AND QUALI-V^®-I EXTRA DRY CAPSULES FOR USE IN DRY POWDER INHALERS
S. A. Parker, K. Roberts, E. Matthews, S. Ecenarro, M. Farag, R. Pullin, J. C. Birchall and S. A. Coulman
Hygroscopic APIs and excipients within capsule-based dry powder inhalers (DPIs) can absorb moisture from the capsule shell [1], which could reduce deagglomeration upon actuation nor degrade moisture-labile APIs…
- 2021_PBP_Comparing the mechanical properties of Quali-V^®-I and Quali-V^®-I Extra Dry
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HOW IMPORTANT IS INTERNAL LUBRICANT IN CAPSULES FOR INHALATION?
M. Stankovic-Brandl, T. Wutscher, S. Ecenarro, L. Canalejas, S. Biserni, A. Mercandelli, M. Kobler, L.Andrade, V. Daza, F. Buttini, A. Paudel
Hypromellose (HPMC) inhalation grade capsules are made by dipping stainless steel mold pins into the warm polymer solution, polymer drying and film formation. To safely remove capsule from pins, pins are previously coated with a surface lubricant…
- 2021_PBP_How important is internal lubricant in capsules for inhalation
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INFLUENCE OF EXTERNAL LUBRICATION ON THE PUNCTURING PROPERTIES OF HARD CAPSULES FOR DRY POWDER INHALATIONS
T. Wutscher, M. Stankovic-Brandl, S. Zellnitz, S. Biserni, A. Mercandelli, M. Kobler, F. Buttini, L. Andrade, V. Daza, S. Ecenarro, L. Canalejas, A. Paudel
After capsule production, external lubricants are applied to prevent the capsules from sticking together and to facilitate processing in a capsule filling machine1. When piercing capsules in a dry powder inhaler, the mechanical properties of the capsule materials play a major role in terms of …
- 2020_AAPS_The influence of external lubrication on the puncturing properties
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INFLUENCE OF EXTERNAL LUBRICATION OF HARD CAPSULES ON THEIR HYGRO-MECHANICAL PROPERTIES, IN-PROCESS TRIBO-CHARGING AND AERODYNAMIC PERFORMANCE OF DPI
T. Wutscher, M. Stankovic-Brandl, S. Zellnitz, M. Kobler, F. Buttini, V. Chierici, L. Andrade, V. Daza, A. Mercandelli, S. Biserni, S. Ecenarro Probst, L. Canalejas and A. Paudel
Hard capsules are often coated with an external lubricant to improve their flow properties during filling and prevent sticking to each other during processing and storage. The external lubrication can impact mechanical strength, surface roughness and tribocharging behaviour ….
- 2020_RDD_Influence of external lubrication of hard capsules
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CAPSULE FILLING PROCESS-INDUCED TRIBO-CHARGING BEHAVIOUR OF HPMC AND
GELATIN CAPSULES WITH DIFFERENT EXTERNAL LUBRICANTS

Thomas Wutscher, Milica Stankovic-Brandl, Sarah Zellnitz, Mirjam Kobler, Francesca Buttini, Laura Andrade, Veronica Daza, Alberto Mercandelli, Stefano Biserni, Guerino D’Elpidio, Susana Ecenarro, Amrit Paudel
Electrostatic charging of powders and materials can negatively impact the manufacturing of inhalation products. During capsule filling, tribo-charging of the capsules induced by the contact with the capsule filler components could lead…
- 2019_DDL_Capsule filling process-induced tribo-charging behaviour of HPMC and gelatin capsules
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DETERMINING THE PUNCTURE PERFORMANCE OF QUALI-V^®-I HYDROXYPROPYLMETHYLCELLULOSE CAPSULES AT VERY LOW MOISTURE CONTENTS
Siamac A. Parker, Susana Ecenarro, Mahmoud Farag, Rhys Pullin, James C. Birchall and Sion A. Coulman
The aim of this study was to characterise the puncture properties of HPMC capsules that have been stored at a RH close to 0%...
- 2019_RDD_Determining the Puncture Performance of Quali-V^®-I
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INFLUENCE OF STORAGE HUMIDITY AND POWDER FILL LEVEL ON CHARGING BEHAVIOUR OF DIFFERENT CAPSULES TYPES
Thomas Wutscher, Sarah Zellnitz, Mirjam Kobler, Francesca Buttini, Laura Andrade, Veronica Daza, Alberto Mercandelli, Stefano Biserni, Susana Ecenarro Probst, Johannes Khinast and Amrit Paudel
In dry powder inhalers (DPIs), tribo-charging can cause problems in terms of mixing homogeneity and dosing accuracy. Further, it can lead to particle adherence on surfaces and agglomeration of particles during manufacturing or powder release from the capsule…
- 2019_RDD_Influence of Storage Humidity and Powder Fill Level on ...
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GLYCEMIC PROFILE IN RATS AFTER PULMONARY ADMINISTRATION OF AN INSULIN DRY POWDER
Buttini F., Chierici V., Quarta E., Flammini L., Clementino A.R., Grandi A., Ecenarro S. , Tognolini M., Barocelli E., Paolo Colombo P., Bettini R.
The aim of this study was to investigate the chemical stability and respirability of an insulin spray-dried powder (Ins_SD) loaded in blister-packed capsules. The in vitro respirability of Ins_SD was compared to one of commercial products, …
- 2018_DDL_Glycemic profile in rats after the administration of an insulin dry powder
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A PERMITTIVITY-GUIDED APPROACH TO DRUG SOLUBILITY SCREENING FOR LIPID-BASED FORMULATIONS
Andreas Niederquell, Gabriela Dujovny, Susana Ecenarro Probst, Martin Kuentz
The aim of this study is to present such permittivity-guided drug solubility screening, which should provide guidance to formulate a model drug (fenofibrate) as a LBDDS...
- 2018_ PBP World meeting_A permittvity-guided approach to drug solubility screening
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A COMPARATIVE EVALUATION OF THE AEROSOLIZATION PERFORMANCES OF MARKETED FLUTICASONE MULTI-UNIT AND SINGLE-UNIT DRY POWDER INHALERS (DPIS): THE EFFECTS OF PRODUCT USE LIFE, SUBOPTIMAL AIRFLOW AND A HOT/HUMID ENVIRONMENT
Nathalie Wauthoz, Ismaël Hennia, Susana Ecenarro and Karim Amighi
In this study, a comparative evaluation was performed on marketed DPIs based on fluticasone propionate (250μg) currently used for maintenance treatment of asthma and chronic obstructive pulmonary disease (COPD)...
- 2017_AAPS_A comparative Evaluation of the Aerosolization Performances of Marketed Fluticasone.pdf
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A COMPATIBILITY TEST OF TWO-PIECE HARD CAPSULES AND LIQUID/SEMI-SOLID EXCIPIENTS
R. Taniguchi, N. Kato, M. Horie
This investigation shows the fundamental compatibility data of two-piece hard capsule and liquid or semi-solid excipients used for liquid formulation...
- 2017_AAPS_A Compatibility Test Of Two-piece Hard Capsules and Liquid-Semi-solid Excipients.pdf
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IMPACT OF CAPSULE TYPE ON THE AERODYNAMIC PERFORMANCES OF A FLUTICASONE PROPIONATE-BASED DRY POWDER UNDER OPTIMAL AND SUBOPTIMAL INHALATION FLOW RATES
Nathalie Wauthoz, Ismaël Hennia, Susana Ecenarro and Karim Amighi
The aim of this work was to evaluate the capsule impact in a higher drug-dosage dry powder using fluticasone propionate (250 μg/25 mg), using different capsules in optimal and in the most relevant suboptimal use conditions (i.e. suboptimal inhalation flow rates)...
- 2017_DDL_Impact of capsule type on the aerodynamic performances of a fluticasone propionate-based.pdf
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A COMPARATIVE EVALUATION OF THE AEROSOLIZATION PERFORMANCES OF MARKETED FLUTICASONE MULTI-UNIT AND SINGLE-UNIT DRY POWDER INHALERS THE EFFECTS OF PRODUCT USE LIFE, SUBOPTIMAL AIRFLOW AND A HOT/HUMID ENVIRONMENT
Nathalie Wauthoz, Ismaël Hennia, Susana Ecenarro and Karim Amighi.
The aim of this study was to evaluate the reproducibility and robustness of the aerosolization performance of a multi-unit DPI and a single-unit DPI reported…
- 2017_RDD_A comparative evaluation of the aerosolization performances of marketed fluticasone
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INVESTIGATION OF PHYSICO-CHEMICAL STABILITY OF A PURE INSULIN SPRAY-DRIED POWDER FOR INHALATION SEMI-AUTOMATICALLY FILLED IN QUALI-V^® CAPSULES
Francesca Buttini, Irene Rossi, Judith Anakayana, Gabriela Dujovny, Karlheinz Seyfang and Paolo Colombo.
In this study, the chemical stability and respirability of this insulin spray-dried powder loaded in capsules and packed in blister was investigated. In particular, the powder was semi-automatically filled in …
- 2017_RDD_Investigation of physico-chemical stability of a pure insulin spray-dried powder for inhalation
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IMPACT OF DIFFERENT CAPSULES FOR DPIS ON THE AERODYNAMIC PERFORMANCES OF FORMOTEROL-BASED BINARY AND TERNARY BLENDS
Nathalie Wauthoz, Ismaël Hennia, Susana Ecenarro and Karim Amighi.
The aim of this work was to evaluate the impact on the aerodynamic performance of two dry powder formulations for inhalation based on formoterol by using different capsules in the Axahaler^® capsule-based DPI…
- 2016_DDL_Impact of different capsules for Dry Powder Inhalers on the aerodynamic performances
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INFLUENCE OF FLOW RATE AND USAGE IN DRASTICCONDITION ON THE AERODYNAMIC PERFORMANCE OF A FORMOTEROL DRY POWDER FORMULATION USING DIFFERENTKINDS OF CAPSULE
Nathalie Wauthoz, Ismaël Hennia, Susana Ecenarro and Karim Amighi.
The aim of this study was to evaluate the aerodynamic performance of a conventional formoterol- based dry powder formulation using 2 types of capsules (hypromellose and gelatin)…
- 2016_AAPS_Influence of Flow Rate and usage in Drastic Condition on the aerodynamic performance
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COMPARISON OF THE DISSOLUTION PROPERTIES OF TWO TYPES OF HPMC (HYPROMELLOSE) CAPSULES FILLED WITH BASIC APIS IN ACID MEDIA II
Makoto Aso, Michikazu Horie.
There are two types of hypromellose capsules, i.e., manufactured by ‘cold gelling’ or ‘thermal gelling’ dipping process, using mold pins kept at room temperature or pre-heated at 50~100ºC, respectively…
- 2016_AAPS_A comparison of the diss. properties of two types of HPMC filled with basic APIs
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INFLUENCE OF DIFFERENT CAPSULES FOR INHALATION ON THE AERODYNAMIC PERFORMANCE OF FORMOTEROL DRY POWDER FORMULATION AT DIFFERENT FLOW RATES
Nathalie Wauthoz, Ismaël Hennia, Susana Ecenarro and Karim Amighi.
An ideal inhalation medicine has to deliver an accurate delivered dose (DD) and fine particle dose (FPD) with low dependency on the patient’s inspiratory airflows…
- 2016_RDD_Influence of different caps. for inhalation on the aerodynamic performance of formoterol
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USING DESIGN OF EXPERIMENTS (DOE) TO OPTIMISE INTERNAL LUBRICANT CONTENT IN INHALATION CAPSULES
Fernando Díez, Maria Teresa Gasso, Guillermo Ayala, Brian Jones, Juan Ramiro Aparicio, Rafael Martin Portugues.
The goal of this work is, through the use of an ANCOVA model, to evaluate the interaction of three manufacturing process parameters in order to produce inhalation capsules with the required internal lubricant content…
- 2015_RDD_Using Design of experiments (DOE) to optimise internal lubricant content
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MARKETED FORMOTEROL INHALATION AEROSOLS: A COMPARATIVE EVALUATION TO DETERMINE THE PLACE OF CAPSULE‐BASED DRY POWDER INHALERS (DPIS)
Nathalie Wauthoz, Ismaël Hennia, Michel Deleers, Fernando Díez and Karim Amighi.
The aim of this study is to compare marketed inhaled medicines based on formoterol, a long‐acting β2 agonist frequently used to treat asthma and chronic obstructive pulmonary disease…
- 2015_RDD_Comparative Evaluation to Determine the Place of Capsule‐based DPIs
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EVALUATION OF THE AERODYNAMIC PERFORMANCE OF FORMOTEROL DRY POWDER USING DIFFERENT CAPSULES FOR INHALATION
Nathalie Wauthoz, Ismaël Hennia, Michel Deleers, Fernando Díez and Karim Amighi.
The aim of this work was to evaluate the impact on the aerodynamic performance of a dry powder based on formoterol and milled lactose with a broad size distribution, using the Axahaler^® DPI and using different kinds of capsules for inhalation (gelatin or hypromellose, HPMC)…
- 2015_DDL_Evaluation of the aerodynamic performance of formoterol dry powder
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INVESTIGATION OF DRY POWDER INHALATIONAEROSOLISATION PERFORMANCE AT DIFFERENTFLOW RATES FROM A CONVENTIONALCAPSULE-BASED INHALER DEVICE
Imran Y Saleem, Rajith KR Rajoli, Brian E Jones, Fernando Díez.
To investigate the aerosolization properties of dry powder formulations composing of inhalation grade lactose and micronized salbutamol…
- 2015_DDL_ Investigation of DPI aerosolization performance at different flow rates
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MOLECULAR WATER INTERACTION IN LIPID-BASED FORMULATIONS AND CAPSULE COMPATIBILITY
Alexandra H. E. Machado, Tohru Kokubo, Gabriela Dujovny, Brian Jones, Claudio Scialdone, Roberto Bravo, Martin Kuentz.
The present study aimed at a better understanding of how water interacts with the formulation and possible effects on capsule compatibility by using time domain nuclear magnetic resonance.…
- 2015_APV_Molecular water interaction in LPF and capsule compatibility
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UNDERSTANDING CAPSULE COMPATIBILITY WITH LIPID-BASED FORMULATIONS: 1. MICROSTRUCTURAL FORMULATION CHANGES WITH AQUEOUS DILUTION AND COMPARISON TO PERCOLATION THEORY
Alexandra H. E. Machado, Tohru Kokubo, Gabriela Dujovny, Brian Jones, Claudio Scialdone, Roberto Bravo, Martin Kuentz.
To study the formation of continuous water channels in lipid based formulations (LBFs) and modeling of the microstructural changes using per collation theory…
- 2015_AAPS_Microstructural formulation changes with aqueous dilution and comparison to percolation theory
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UNDERSTANDING CAPSULE COMPATIBILITY WITH LIPID-BASED FORMULATIONS: 2. ASSESSMENT OF MECHANICAL PROPERTIES OF GELATIN AND HPMC CAPSULES AFTER EQUILIBRATION WITH FORMULATIONS
Alexandra H. E. Machado, Tohru Kokubo, Gabriela Dujovny, Brian Jones, Claudio Scialdone, Roberto Bravo, Martin Kuentz.
To understand how microstructural changes in LBFs due to the presence of water affect compatibility with capsule shells by comparing differences between gelatin and HPMC capsules using mechanical texture analysis.…
- 2015_AAPS_Assessment of mechanical properties of gelatin and HPMC capsules
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A COMPARATIVE EVALUATION OF FORMOTEROL-BASED MARKETED INHALED MEDICINES THROUGHOUT THE DEVICE LIFE, FOCUSING ON INSPIRATORY AIRFLOW AND HIGH TEMPERATURE AND HUMIDITY USE CONDITIONS
Nathalie Wauthoz, Ismaël Hennia, Michel Deleers, Fernando Díez and Karim Amighi.
In this study, a comparative evaluation was performed on 5 formoterol-based marketed inhaled medicines currently used for maintenance treatment of asthma and chronic obstructive pulmonary disease…
- 2015_AAPS_A comparative evaluation of formoterol-based marketed inhaled medicines
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UNDERSTANDING INTRA- AND INTER-INDIVIDUAL DIFFERENCES IN CAPSULE PUNCTURE FOLLOWING ACTUATION OF A DRY POWDER INHALER
Gabriela Dujovny Cerith Morgan, Fernando Díez, James Birchall, Brian Jones, Sion A. Coulman.
The aim of this study is to better understand capsule puncture upon actuation of a capsule loaded DPI by a user…
- 2014_AAPS_Understanding intra- and inter-individual differences in capsule puncture
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THE PUNCTURE PROPERTIES AND THE SHEDDING OF PARTICLES OF CAPSULES IN DRY POWDER INHALERS, EFFECT OF CAPSULE TYPE AND MOISTURE CONTENT
Brian E. Jones, Jeng Chong, Fernando Díez, James C. Birchall, Rosalind Chong, Sion A. Coulman.
The aim of this study was to characterise and measure all particles shed, both visible and those smaller than the visible threshold, upon puncture of gelatin and hypromellose (HPMC) capsules and to examine the effect of capsule moisture on this.…
- 2014_AAPS_Puncture properties and the shedding of particles of capsules in DPIs
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INFLUENCE OF TEMPERATURE ON CAPSULE PUNCTURING PERFORMANCE
Fernando Díez, Rosalind Chong, James Birchall, Brian Jones, Sion Coulman.
The aim of this work was to determine if low temperatures influence the capsule puncturing process by a DPI…
- 2014_AAPS_Influence of temperature on caps. puncturing performance
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INFLUENCE OF INTERNAL LUBRICANT ON POWDER AEROSOLIZATION PROPERTIES FROM INHALATION GRADE HYPROMELLOSE CAPSULES (QUALI-V^®-I)
Imran Y Saleem, Fernando Díez, Brian E Jones.
To investigate aerosolization properties of a model inhalation powder formulation, lactose and micronized salbutamol, from hypromellose capsules with different levels of internal lubricant when used in dry powder inhaler (DPI)…
- 2013_AAPS_Influence of internal lubricant on powder aerosolization properties
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ELECTROSTATIC CHARGING BEHAVIOR OF GELATIN AND HPMC HARD CAPSULES
Frank Thielmann, Tomohito Nakao, Toshimitsu Usui, Tohru Kokubo, Fernando Diez, Jerry Y.Y. Heng, and Daniel Burnett.
Triboelectrification is caused by friction that occurs during transport, processing and testing and leads to formulation and manufacturing issues. Electrostatics also plays a major role in design and use of hard capsules. In this paper, the impact of surface modifications of HMPC and gelatin capsules…
- 2013_AAPS_Electrostatic charging behavior of gelatin and HPMC hard capsules
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THE DEVELOPMENT OF A ROBUST METHODOLOGY TO EVALUATE INHALATION CAPSULE PUNCTURE PERFORMANCE
F. Díez, B. Torrisi, J.C. Birchall, S.A. Coulman, B. E. Jones.
This study aimed to develop a robust methodology to determine potential differences in the puncture characteristics of different capsule materials, to assist in the development of hard capsules for this application.…
- 2013_AAPS_Development of a robust methodology to evaluate inhalation capsule puncture performance
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CHARACTERISING CAPSULE PUNCTURE OF DIFFERENT CAPSULE TYPES FOLLOWING PATIENT ACTUATION OF A DRY POWDER INHALER
B.E. Jones, Z. Atrah, S.A. Coulman, J.C. Birchall, F. Díez.
The aim of this study is to characterise the puncture performance of HPMC and gelatin capsules when perforated by a two-pin DPI operated by a member of the public to determine the inter- and intra- individual variability…
- 2013_AAPS_Characterising capsule puncture of different capsule types
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A COMPARISON OF TWO DIFFERENT TYPES OF INHALATION CAPSULES & INHALER DEVICE ON POWDER AEROSOLISATION
Imran Y Saleem, Fernando Díez, Brian E Jones.
The aim of this study was to compare the aerosolization properties [emitted dose (ED), fine particle fraction (FPF) and the mass median aerodynamic diameter (MMAD)] of a typical powder formulation…
- 2012_AAPS_Comparison of Two Different Types of Inhalation Capsules on powder aerosolization
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A COMPARISON OF THE DISSOLUTION PROPERTIES OF 2 HPMC (HYPROMELLOSE) CAPSULES FILLED WITH BASIC COMPOUNDS IN ACID MEDIA
Yoshiro Osaki, Toshimitsu Usui and Tohru Kokubo.
In this study, we investigated dissolution from 2 types of hypromellose capsules to clarify these claims and to find out if basic groups interfere with dissolution from capsules manufactured with carrageenan…
- 2012_AAPS_Comparison of the dissolution properties of 2 HPMC capsules filled with different compound
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EVALUATION OF THE PROPERTIES OF HPMC CAPSULES MANUFACTURED USING DIFFERENT METHODS
Tomo Uyama, Asami Inui, Tohru Kokubo.
In this study, the factors important for capsule performance, dissolution, brittleness and moisture content were evaluated on films and commercially available HPMC capsules manufactured by these 2 methods…
- 2010_AAPS_Evaluation of the properties of HPMC capsules manufactured using different methods
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scientific posters

COMPARING THE MECHANICAL PROPERTIES OF QUALI-V®-I AND QUALI-V®-I EXTRA DRY CAPSULES FOR USE IN DRY POWDER INHALERS

HOW IMPORTANT IS INTERNAL LUBRICANT IN CAPSULES FOR INHALATION?

INFLUENCE OF EXTERNAL LUBRICATION ON THE PUNCTURING PROPERTIES OF HARD CAPSULES FOR DRY POWDER INHALATIONS

INFLUENCE OF EXTERNAL LUBRICATION OF HARD CAPSULES ON THEIR HYGRO-MECHANICAL PROPERTIES, IN-PROCESS TRIBO-CHARGING AND AERODYNAMIC PERFORMANCE OF DPI

CAPSULE FILLING PROCESS-INDUCED TRIBO-CHARGING BEHAVIOUR OF HPMC AND GELATIN CAPSULES WITH DIFFERENT EXTERNAL LUBRICANTS

DETERMINING THE PUNCTURE PERFORMANCE OF QUALI-V®-I HYDROXYPROPYLMETHYLCELLULOSE CAPSULES AT VERY LOW MOISTURE CONTENTS

INFLUENCE OF STORAGE HUMIDITY AND POWDER FILL LEVEL ON CHARGING BEHAVIOUR OF DIFFERENT CAPSULES TYPES

GLYCEMIC PROFILE IN RATS AFTER PULMONARY ADMINISTRATION OF AN INSULIN DRY POWDER

A PERMITTIVITY-GUIDED APPROACH TO DRUG SOLUBILITY SCREENING FOR LIPID-BASED FORMULATIONS

A COMPARATIVE EVALUATION OF THE AEROSOLIZATION PERFORMANCES OF MARKETED FLUTICASONE MULTI-UNIT AND SINGLE-UNIT DRY POWDER INHALERS (DPIS): THE EFFECTS OF PRODUCT USE LIFE, SUBOPTIMAL AIRFLOW AND A HOT/HUMID ENVIRONMENT

A COMPATIBILITY TEST OF TWO-PIECE HARD CAPSULES AND LIQUID/SEMI-SOLID EXCIPIENTS

IMPACT OF CAPSULE TYPE ON THE AERODYNAMIC PERFORMANCES OF A FLUTICASONE PROPIONATE-BASED DRY POWDER UNDER OPTIMAL AND SUBOPTIMAL INHALATION FLOW RATES

A COMPARATIVE EVALUATION OF THE AEROSOLIZATION PERFORMANCES OF MARKETED FLUTICASONE MULTI-UNIT AND SINGLE-UNIT DRY POWDER INHALERS THE EFFECTS OF PRODUCT USE LIFE, SUBOPTIMAL AIRFLOW AND A HOT/HUMID ENVIRONMENT

INVESTIGATION OF PHYSICO-CHEMICAL STABILITY OF A PURE INSULIN SPRAY-DRIED POWDER FOR INHALATION SEMI-AUTOMATICALLY FILLED IN QUALI-V® CAPSULES

IMPACT OF DIFFERENT CAPSULES FOR DPIS ON THE AERODYNAMIC PERFORMANCES OF FORMOTEROL-BASED BINARY AND TERNARY BLENDS

INFLUENCE OF FLOW RATE AND USAGE IN DRASTICCONDITION ON THE AERODYNAMIC PERFORMANCE OF A FORMOTEROL DRY POWDER FORMULATION USING DIFFERENTKINDS OF CAPSULE

COMPARISON OF THE DISSOLUTION PROPERTIES OF TWO TYPES OF HPMC (HYPROMELLOSE) CAPSULES FILLED WITH BASIC APIS IN ACID MEDIA II

INFLUENCE OF DIFFERENT CAPSULES FOR INHALATION ON THE AERODYNAMIC PERFORMANCE OF FORMOTEROL DRY POWDER FORMULATION AT DIFFERENT FLOW RATES

USING DESIGN OF EXPERIMENTS (DOE) TO OPTIMISE INTERNAL LUBRICANT CONTENT IN INHALATION CAPSULES

MARKETED FORMOTEROL INHALATION AEROSOLS: A COMPARATIVE EVALUATION TO DETERMINE THE PLACE OF CAPSULE‐BASED DRY POWDER INHALERS (DPIS)

EVALUATION OF THE AERODYNAMIC PERFORMANCE OF FORMOTEROL DRY POWDER USING DIFFERENT CAPSULES FOR INHALATION

INVESTIGATION OF DRY POWDER INHALATIONAEROSOLISATION PERFORMANCE AT DIFFERENTFLOW RATES FROM A CONVENTIONALCAPSULE-BASED INHALER DEVICE

MOLECULAR WATER INTERACTION IN LIPID-BASED FORMULATIONS AND CAPSULE COMPATIBILITY

UNDERSTANDING CAPSULE COMPATIBILITY WITH LIPID-BASED FORMULATIONS: 1. MICROSTRUCTURAL FORMULATION CHANGES WITH AQUEOUS DILUTION AND COMPARISON TO PERCOLATION THEORY

UNDERSTANDING CAPSULE COMPATIBILITY WITH LIPID-BASED FORMULATIONS: 2. ASSESSMENT OF MECHANICAL PROPERTIES OF GELATIN AND HPMC CAPSULES AFTER EQUILIBRATION WITH FORMULATIONS

A COMPARATIVE EVALUATION OF FORMOTEROL-BASED MARKETED INHALED MEDICINES THROUGHOUT THE DEVICE LIFE, FOCUSING ON INSPIRATORY AIRFLOW AND HIGH TEMPERATURE AND HUMIDITY USE CONDITIONS

UNDERSTANDING INTRA- AND INTER-INDIVIDUAL DIFFERENCES IN CAPSULE PUNCTURE FOLLOWING ACTUATION OF A DRY POWDER INHALER

THE PUNCTURE PROPERTIES AND THE SHEDDING OF PARTICLES OF CAPSULES IN DRY POWDER INHALERS, EFFECT OF CAPSULE TYPE AND MOISTURE CONTENT

INFLUENCE OF TEMPERATURE ON CAPSULE PUNCTURING PERFORMANCE

INFLUENCE OF INTERNAL LUBRICANT ON POWDER AEROSOLIZATION PROPERTIES FROM INHALATION GRADE HYPROMELLOSE CAPSULES (QUALI-V®-I)

ELECTROSTATIC CHARGING BEHAVIOR OF GELATIN AND HPMC HARD CAPSULES

THE DEVELOPMENT OF A ROBUST METHODOLOGY TO EVALUATE INHALATION CAPSULE PUNCTURE PERFORMANCE

CHARACTERISING CAPSULE PUNCTURE OF DIFFERENT CAPSULE TYPES FOLLOWING PATIENT ACTUATION OF A DRY POWDER INHALER

A COMPARISON OF TWO DIFFERENT TYPES OF INHALATION CAPSULES & INHALER DEVICE ON POWDER AEROSOLISATION

A COMPARISON OF THE DISSOLUTION PROPERTIES OF 2 HPMC (HYPROMELLOSE) CAPSULES FILLED WITH BASIC COMPOUNDS IN ACID MEDIA

EVALUATION OF THE PROPERTIES OF HPMC CAPSULES MANUFACTURED USING DIFFERENT METHODS

COMPARING THE MECHANICAL PROPERTIES OF QUALI-V^®-I AND QUALI-V^®-I EXTRA DRY CAPSULES FOR USE IN DRY POWDER INHALERS

CAPSULE FILLING PROCESS-INDUCED TRIBO-CHARGING BEHAVIOUR OF HPMC AND
GELATIN CAPSULES WITH DIFFERENT EXTERNAL LUBRICANTS

DETERMINING THE PUNCTURE PERFORMANCE OF QUALI-V^®-I HYDROXYPROPYLMETHYLCELLULOSE CAPSULES AT VERY LOW MOISTURE CONTENTS

INVESTIGATION OF PHYSICO-CHEMICAL STABILITY OF A PURE INSULIN SPRAY-DRIED POWDER FOR INHALATION SEMI-AUTOMATICALLY FILLED IN QUALI-V^® CAPSULES

INFLUENCE OF INTERNAL LUBRICANT ON POWDER AEROSOLIZATION PROPERTIES FROM INHALATION GRADE HYPROMELLOSE CAPSULES (QUALI-V^®-I)