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PROVIDING PREMIUM PROFIT THROUGH THE CAPSULE ORAL DOSAGE FORM ALONG THE WHOLE DRUG PRODUCT LIFE CYCLE
Canalejas, L., Gurruchaga, L., 2021, Manufacturing Chemist.
Drug product formulators and manufacturers often choose tablets instead of capsules as a cost-effective dosage form. When developing a medicine, however, there are a lot of variables that come into play and are influenced by the final format. In this article, the main steps of the drug product lifecycle…
- 2021_ManufacturingChemist_Providing premium profit through the capsule oral dosage form
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FORMULATION SOLUTION FOR MOISTURE-SENSITIVE DRUGS
Canalejas, L., 2021, On Drug Delivery.
It is well known that moisture affects the performance of some drug products, presenting a fierce challenge in the formulation of oral dosage forms. Moisture may have a significant impact on a wide range of chemical, physical, and microbial properties of the finished pharmaceutical product, leading to…
- 2021_OnDrugDelivery_Formulation solution for moisture-sensitive drugs
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EVALUATING THE MECHANICAL PROPERTIES OF “EXTRA DRY” HARD-SHELL CAPSULES
Coulman, S., Parker, S., Birchall, J., Ecenarro, S., Farag M., 2020, On Drug Delivery.
Dry powder inhalers (DPIs) are breath-actuated devices used to deliver drugs to the lung for local or systemic therapy. A DPI consists of two principal components, the inhaler device and a reservoir containing the micronised dry powder formulation. Hard-shell capsules….
- 2020_OnDrugDelivery_Evaluating the mechanical properties of “extra dry” capsules
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QUALI-V EXTRA DRY: A NOVEL CAPSULE FOR DELIVERING HYGROSCOPIC PHARMACEUTICAL DRUGS
Encinas, J.L., Ecenarro, S., 2019, On Drug Delivery.
In this article, Jose Luis Encinas, Engineering & Continuous Improvement Manager, and Susana Ecenarro, Director of Scientific Business Development, both of Qualicaps Europe, explore how the use of Quali-V® Extra Dry capsules can help improve product stability ….
- 2019ONdrugDeliveryQV ExtraDry a novel capsule for delivering hygroscopic pharmaceutical drugs
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VERSATILIDADE DAS CÁPSULAS DURAS NO DESENVOLVIMENTO DE NOVAS PRODUTOS
Debora Custodio Moura PhD., 2018 Pharmaceutical Technology
O desenvolvimento de um novo produto exige a definição de uma série de parámetros técnicos e comerciais, além do envolvimento de distintas áreas dentro da companhia. A importancia de estar presente no mercado com novidades tem sido uma exigencia para…
- 2018_Pharmaceutical technology_Versatilidade das cápsulas duras no desenvolvimento de novos productos
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INHALABLE THERAPEUTIC BIOLOGICS, A PARADIGM SHIFT FOR NON-INVASIVE EFFICIENT MEDICAL TREATMENTS
Buttini, F., Ecenarro, S., 2018, On Drug Delivery
In this article, Francesca Buttini, PhD, Associate Professor, University of Parma, and Susana Ecenarro Probst, Director of Scientific Business Development, Qualicaps, discuss the rising prominence of biologics in the pharmaceuticals market and…
- 2018_OnDrugDelivery_Inhalable therapeutic biologics a Paradigm shift for non-invasive efficient medical treatments
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Impact of capsule type on aerodynamic performance of inhalation products: A case study using a formoterol-lactose binary or ternary blend
Nathalie Wauthoz, Ismaël Hennia, Susana Ecenarro, Karim Amighi. 2018, International Journal of Pharmaceutics
The aerodynamic performance of a dry powder for inhalation depends on the formulation and the dry powder inhaler (DPI). In the case of capsule-based DPIs, the capsule also plays a role in the powder aerosolisation and the dispersion of the micronized drug during the inhalation. This study evaluated the impact of gelatine capsules (Quali-G™ and Hard Gelatine Capsules for DPIs)...
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SELECTING THE FINAL SODF: A COMPARISON OF CAPSULES AND TABLETS
Ecenarro, S., 2017, Tablets and Capsules.
Hard capsules, also known as two-piece capsules, offer an extremely versatile drug delivery method. Most are dry-filled with powders, granules, pellets, tablets, or mini-tablets. But hard capsules also…
- 2017_Tablets and capsules_Selecting the Final SODF
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AN OVERVIEW OF DRY POWDER INHALATION FOR SYSTEMIC DRUG DELIVERY
Jones, B.E, Ecenarro, S., 2017, On Drug Delivery.
Interest is growing in the treatment of systemic diseases using active pharmaceutical ingredients (APIs) administered via inhalation, a method especially applicable to the delivery of biomolecules…
- 2017_OnDrugDelivery_An overview of DPI for systemic drug delivery
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CAN YOU FILL HPMC CAPSULES WITH HYGROSCOPIC FORMULATIONS?
Jones B.E, 2017, Tablets and capsules.
Many of the early papers that addressed capsules made from hydroxypropyl methylcellulose (HPMC), or hypromellose, included comments about their moisture content, …
- 2017_ Can you fill HPMC capsules with hygroscopic formulations
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IMAGING TECHNIQUES FOR DPI CAPSULES
Birchall J., Coulman S., Ecenarro S., Jones B., Whiteside B., 2017, Inhalation.
Dry powder inhalers (DPIs) that employ drugloaded, two-piece capsules for pulmonary drug delivery have been in use for more than 45 years …
- 2017_Inhalation_ Imaging techniques for DPI capsules
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THE CAPSULE-BASED DPI, AN ENVIRONMENTALLY FRIENDLY AND EFFICIENT DRUG DELIVERY DOSAGE FORM
Ecenarro, S., 2016, On Drug Delivery
Set against the backdrop of environmental concerns over HFC propellants used in pressurised metered-dose inhalers, Susana Ecenarro Probst, MBA, Director of Scientific Business Development, …
- Capsule-based DPI, environmentally and friendly dosage form
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CAPSULE-BASED DRY-PoWDER INHALERS, AN OPTIMAL SOLUTION FOR DIFFERENT INSPIRATIONAL RATES
Dujovny, G., 2016, On Drug delivery.
There is a wide range of devices available to deliver inhalation therapies, but there is increasing interest in the use of dry powder inhalers (DPIs)…
- 2016_OnDrugDelivery_Capsule-based DPI, an optimal solution for different inspirational rates
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FORMULATING WITH LIQUIDS: TWO-PIECE OR SOFTGEL CAPSULES?
Roberson, A., 2016, Tablets and Capsules.
Liquid fills can deliver active pharmaceutical ingredients (APIs) that are otherwise difficult or impossible to deliver via other solid dosage forms.…
- 2016_Tablets and capsules_Formulating with liquids,two-pieces or softgel capsules
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ADVANTAGES OF CAPSULE-BASED DRY POWDER INHALERS
Jones, B.E., Díez, F., 2015, Inhalation.
HPMC capsules used in DPIs can provide key advantages in inhalation parameters. Direct pulmonary drug delivery originated as a more relevant alternative for administering drugs directly to the lungs…
- 2015_Inhalation_Advantages of capsules-based DPI
  
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NUEVAS APLICACIONES DE LAS CÁPSULAS FARMACÉUTICAS. INHALACIÓN DE MEDICAMENTOS
Díez, F., 2014, Farmaespaña industrial.
It is estimated that the number of operations, since the molecule is synthesized until the drug is available for clinical trials, ...
- 2014_Farmaespaña industrial_Nuevas aplicaciones de las cápsulas farmacéuticas
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A SIMPLE TEST TO DIFFERENTIATE GELATIN FROM HYPROMELLOSE CAPSULES
Requejo, E., Díez, F., Polo, L., Kayali, N., 2013, Tablets and Capsules.
This article describes how to use FT-IR spectroscopy to differentiate gelatin from hypromellose capsules, enabling quick verification of incoming capsule samples…
- 2013_Tablets and capsules_ IR to differentiate HPMC from gelatin capsules
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AEROSOLISATION PROPERTIES OF QUALI-V^®-I VERSUS GELATIN CAPSULES: AN IMPROVEMENT IN INHALATION DRUG DELIVERY
Jones, B.E., Saleem, I.Y., Díez, F., 2013, On Drug Delivery.
In this article, Imran Saalem, PhD, Senior Lecturer, Pharmaceutical Technology, Pharmacy & Biomolecular Sciences, Liverpool JMU, Liverpool, UK, Fernando Díez, Business Development Manager, Qualicaps…
- 2013_OnDrugDelivery_Aerosolisation Properties of Quali-V^®-I vs. gelatin capsules
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to cap it all
Díez, F., 2012, World Pharmaceuticals frontiers, 434, 503– 506.
Patented in the 19th century, two-piece capsules have played a prominent part in the pharmaceutical sector. For much of that period, gelatin capsules…
- 2012_World Pharmaceutical frontiers_ To cap it all
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PULMONARY DELIVERY & DRY-POWDER INHALERS: ADVANCED IN HARD-CAPSULE TECHNOLOGY
Jones, B.E., Díez, F., 2010, On Drug Delivery.
Here, Fernando Díez, Business Development Manager at Qualicaps Europe, and Brian Jones, Scientific Advisor to the company, describe the development of capsules for dry-powder inhalers, …
- 2010_On drug delivery_DPI. Advances on hard-capsules technology
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Time capsules: the hard two-piece capsule, a history of continuous change and improvement
Jones B.E, 2009 Pharmaceutical Processing.
The hard two-piece capsule has always carried an allure of being modern and up-to-date despite the fact that capsules have been in widespread use in the U.S. since the 1880s, …
- 2009_ Time capsules: the hard two-piece capsule, a history of continuous change
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THE EVOLUTION OF DPI CAPSULES
Jones, B.E., 2008, Inhalation.
Almost 40 years ago, Fisons Pharmaceutical Division introduced the Spinhaler device, making it the first company to use a hard gelatin capsule as a single dose container…
- 2008_Inhalation_The evolution of DPI capsules
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articles

PROVIDING PREMIUM PROFIT THROUGH THE CAPSULE ORAL DOSAGE FORM ALONG THE WHOLE DRUG PRODUCT LIFE CYCLE

FORMULATION SOLUTION FOR MOISTURE-SENSITIVE DRUGS

EVALUATING THE MECHANICAL PROPERTIES OF “EXTRA DRY” HARD-SHELL CAPSULES

QUALI-V EXTRA DRY: A NOVEL CAPSULE FOR DELIVERING HYGROSCOPIC PHARMACEUTICAL DRUGS

VERSATILIDADE DAS CÁPSULAS DURAS NO DESENVOLVIMENTO DE NOVAS PRODUTOS

INHALABLE THERAPEUTIC BIOLOGICS, A PARADIGM SHIFT FOR NON-INVASIVE EFFICIENT MEDICAL TREATMENTS

Impact of capsule type on aerodynamic performance of inhalation products: A case study using a formoterol-lactose binary or ternary blend

SELECTING THE FINAL SODF: A COMPARISON OF CAPSULES AND TABLETS

AN OVERVIEW OF DRY POWDER INHALATION FOR SYSTEMIC DRUG DELIVERY

CAN YOU FILL HPMC CAPSULES WITH HYGROSCOPIC FORMULATIONS?

IMAGING TECHNIQUES FOR DPI CAPSULES

THE CAPSULE-BASED DPI, AN ENVIRONMENTALLY FRIENDLY AND EFFICIENT DRUG DELIVERY DOSAGE FORM

CAPSULE-BASED DRY-PoWDER INHALERS, AN OPTIMAL SOLUTION FOR DIFFERENT INSPIRATIONAL RATES

FORMULATING WITH LIQUIDS: TWO-PIECE OR SOFTGEL CAPSULES?

ADVANTAGES OF CAPSULE-BASED DRY POWDER INHALERS

NUEVAS APLICACIONES DE LAS CÁPSULAS FARMACÉUTICAS. INHALACIÓN DE MEDICAMENTOS

A SIMPLE TEST TO DIFFERENTIATE GELATIN FROM HYPROMELLOSE CAPSULES

AEROSOLISATION PROPERTIES OF QUALI-V®-I VERSUS GELATIN CAPSULES: AN IMPROVEMENT IN INHALATION DRUG DELIVERY

to cap it all

PULMONARY DELIVERY & DRY-POWDER INHALERS: ADVANCED IN HARD-CAPSULE TECHNOLOGY

Time capsules: the hard two-piece capsule, a history of continuous change and improvement

THE EVOLUTION OF DPI CAPSULES

AEROSOLISATION PROPERTIES OF QUALI-V^®-I VERSUS GELATIN CAPSULES: AN IMPROVEMENT IN INHALATION DRUG DELIVERY